Abstract
Does acupuncture to apply in treatment make worthwhile differences to primary care patients with migraine? To study of the relevant literature to evaluate the effectiveness and efficacy in order to point out certain evidence in future.
Traditional Chinese medicine (TCM) is a medical science that is based on clinical experience of the wisdom of ancestors. From the earliest records, human was the object of treatment, and accumulated abundant records were handed down as reference for later generations of doctors.
The electronic databases (PubMed ,Medline, Complementary Medicine) search using the terms “acupuncture” and “migraine” selected relevant publications. Based on this critical evaluation of the literature and the derivation of these indicators, we conclude SCI twenty-one articles available that acupuncture therapy is related with migraine which supported with certain evidence in research.
Keywords: Acupuncture, Migraine, Traditional Chinese Medicine
Introduction
Migraine (from the Greek words hemi, meaning half, and kranion, meaning skull) is a chronic neurological disorder characterized by moderate to severe headaches, and nausea. It is about 3 or 4 times more common in women than in men. A typical attack lasts between 4 and 72 hours. Which is one of the most common causes of patients’ seeking attention at neurology clinics, is a highly prevalent health problem and one with considerable socioeconomic impact? 1-4 The International Headache Society (HIS) differentiates each type of headaches based on the number of attacks per month, length of time per attack, characteristics of the pain, and other accompanying symptoms.
According to HIS(1988) report, Migraine afflicts 28 million Americans, with females suffering more frequently (17%) than males (6%). in persons between the ages of 25 and 55 years, In Spain, the prevalence of migraine is 16.9% among women and 7.4% among men 5, with 60% of patients having a family background of such headaches.6 some women who suffer from migraine headaches experience more headaches around the time of their menstrual periods.
This epidemiologic profile is similar to that reported for other countries, but lower in China. 7-9
Modern scientific research has established the following mechanisms for headaches. Headache pain begins with the trigeminal nerve, which is located in the brain stem and carries sensory impulses to and from the face. When the trigeminal nerve is stimulated by a headache trigger such as anxiety, glare, noise, anger, improper diet, medications, or hormones, a burst of neurotransmitters is released. One of these neurotransmitters, serotonin, has the function of screening out "unimportant" signals to the brain, and admitting signals that demand attention. Serotonin fluctuation is the biochemical and neurological foundation of understanding headaches. Low serotonin levels make people more vulnerable to headaches.10
Traditional Chinese medicine differentiate groups of symptoms into a specific pattern, A headache pattern may be caused by external effects, such as chemicals, weather, and other environmental factors; or by internal imbalances, The most commonly-encountered headache patterns, such as : Wind Cold,. Wind Heat, Wind Dampness, Liver Yang arising, Kidney Deficiency, Blood Deficiency, Blood Stagnation, Phlegm Retention.
Materials and Methods
Data Source
The main source for the information used in this study was the PubMed database. This resource is updated weekly and accessible from the National Centre for Biotechnology Information (NCBI) of the US National Library Medicine via the Internet, where users may retrieve data without charge. Medline database was also used with the same search strategy for correcting the database bias.
The main source for the information used in this study was the PubMed database. This resource is updated weekly and accessible from the National Centre for Biotechnology Information (NCBI) of the US National Library Medicine via the Internet, where users may retrieve data without charge. Medline database was also used with the same search strategy for correcting the database bias.
Data Selection
The results of studies relating to migraine , the findings of systematic reviews, and relevant clinical cases were collected from a PubMed search following a search strategy, for the words “acupuncture” and “migraine”, and the search limits as following conditions: publication date to 2008/01/01, only items with abstracts and English.
The results of studies relating to migraine , the findings of systematic reviews, and relevant clinical cases were collected from a PubMed search following a search strategy, for the words “acupuncture” and “migraine”, and the search limits as following conditions: publication date to 2008/01/01, only items with abstracts and English.
Acupuncture for Headaches
Acupuncture is not only effective for migraine headaches, but also works very well with tension headaches, cluster headaches, post-traumatic headaches, and disease-related headaches that might be due to sinus problems, TMJ, stroke, high blood pressure, or sleeping disorders.11
In an open, randomized trial, evaluated by Allias et al.(2003), sixty women suffering from transformed migraine were assigned, after a one month run-in period, to three different treatments: TENS (Group T; n=20), infrared lasertherapy (Group L; n=20) or acupuncture (Group A; n=20). In each group the patients underwent ten sessions of treatment and monthly control visits. A basic formula (LR3, SP6, LI4, GB20, GV20 and Ex-HN5) was always employed; additional points were selected according to each patient's symptomatology. The number of days with headache per month significantly decreased during treatment in all groups. The response in the groups differed over time, probably due to the different timing of applications of the three methods. TENS, lasertherapy and acupuncture proved to be effective in reducing the frequency of headache attacks. Acupuncture showed the best effectiveness over time. 12
Critique point: The prevalence of migraine is 16.9% among women and 7.4% among men, some women who suffer from migraine experience around the time of their menstrual periods. Further research is needed to determine the extent to which variability in male or other acupuncture point selection among acupuncturists and affects clinical outcomes. In calculating the sample size seems too small be undertaken 60 females only. We propose to recruit more patients (around 300 patients) in order to allow for a 20% withdrawal rate. |
The Remy R. et al. (2006) also indicated that some variation in TCM pattern diagnosis and point selection for persons with frequent headache was observed for all subjects. This study point out Liver Yang and Qi dysfunction were diagnosed in more than two thirds of subjects. Acupuncture points LR3, LI4, and GV20 were the most commonly selected points for treatment.16
Critique point: There is variability among acupuncturists in the diagnosis of TCM patterns and the selection of acupuncture points or channel for needling. A treatment manual provides a precise way to train and supervise practitioners, enable evaluation of conformity and competence,facilitate the training process, and increase the ability to identify the active therapeutic ingredients in clinical trials of acupuncture. |
In Germany, Linde K, et al., (2005) investigated the effectiveness of acupuncture compared with sham acupuncture and with no acupuncture in patients with migraine. Three-group, randomized, controlled trial (April 2002-January 2003) involving 302 patients (88% women), mean (SD) age of 43 (11) years, with migraine headaches, based on International Headache Society criteria. Acupuncture, sham acupuncture, or waiting list control. Acupuncture and sham acupuncture were administered by specialized physicians and consisted of 12 sessions per patient over 8 weeks. Patients completed headache diaries from 4 weeks before to 12 weeks after randomization and from week 21 to 24 after randomization.
Acupuncture was no more effective than sham acupuncture in reducing migraine headaches although both interventions were more effective than a waiting list control. The measure outcomes as follows.13
·No difference was detected between the acupuncture and the sham acupuncture groups (0.0 days, 95% confidence interval, -0.7 to 0.7 days; P = .96)
·While there was a difference between the acupuncture group compared with the waiting list group (1.4 days; 95% confidence interval; 0.8-2.1 days; P<.001)
Critique point: Too high rate in women (88%), we need to concern the participant (male or both) in future. According to which each activity consumes resources (inputs) – personal, materials and pharmaceutical – in order to produce results (outputs). Characteristic diagnostic variables according to traditional Chinese medicine the following factors: (1) the location of the headache; (2) the meridian or meridians most likely to be involved; (3) internal factors such as Blood, Qi, Yin, Yang, etc.; (4) external pathogens such as Wind, Phlegm, Cold, etc.; (5) the internal organs affected; (6) the state of internal body functions such as Stagnation, Excess, or Deficiency. |
The GERAC Migraine Study Group in Germany, A multicentre randomised controlled clinical trial by Diener HC et al., (2006) assessed the efficacy of acupuncture for the prophylaxis of migraine. This study was a prospective, randomised, multicentre, double-blind, parallel-group, controlled, clinical trial, undertaken between April 2002 and July 2005. Patients who had two to six migraine attacks per month were randomly assigned verum acupuncture (n=313), sham acupuncture (n=339), or standard therapy (n=308). Patients received ten sessions of acupuncture treatment in 6 weeks or continuous prophylaxis with drugs. Primary outcome was the difference in migraine days between 4 weeks before randomisation and weeks 23-26 after randomisation. 14
The primary outcome showed a mean reduction of day as follows:
· 2 .3 days (95% CI 1.9-2.7) in the verum acupuncture group.
· 1.5 days (1.1-2.0) in the sham acupuncture group.
· 2.1 days (1.5-2.7) in the standard therapy group.
These differences were statistically significant compared with baseline (p<0.0001), but not across the treatment groups (p=0.09). The proportion of responders, defined as patients with a reduction of migraine days by at least 50%, 26 weeks after randomisation, was 47% in the verum group, 39% in the sham acupuncture group, and 40% in the standard group (p=0.133). Treatment outcomes for migraine do not differ between patients treated with sham acupuncture, verum acupuncture, or standard therapy.
Critique point: Monitoring data and side effects: Records will be kept of all side effects that are reported, and possible adverse events caused by the experimental treatment or the medication provided, and stating the date of occurrence. Sociodemographic variables related to the severity of the problem, occupational aspects and an estimation of direct tangible costs. |
Discussion and Conclusion
The objective was to assess whether there is evidence that acupuncture is more or similarly effective than other interventions in the treatment of migraine headaches.
Our literature search did not identify eligible trials from China, Taiwan and Korea where acupuncture is widespread. As the literature from these countries in only partially covered by most data bases it might be that unidentified eligible trials from these countries exist. Evidence from these countries has to be interpreted with caution as almost positive results by researchers.15-17
Assessing chronic headaches in a clinically meaningful manner is a complex issue that involved intensity, duration, medication needs, accompanying symptoms, mood, social functioning, daily activity, and workdays lost are all relevant indicators. The evidence derived from such trials might underestimate the benefits from acupuncture treatment. More pragmatic trials comparing acupuncture with no prophylactic treatment and other prophylactic interventions are needed to evaluate effectiveness and efficiency under real life conditions
Although randomized controlled trials (RCTs) are the gold standard for evidence, it is also important to synthesize the available evidence when there is no or few RCT in interesting area. Overall, the existing evidence suggests that acupuncture has a role in the treatment of Migraine headaches. However, the quality and amount of evidence is not fully convincing. There is urgent need for well-planned, large-scale studies to assess effectiveness and efficiency of standard operating procedures (SOP) for acupuncture.18
The British Professor Archie Cochrane, his book “Effectiveness and Efficiency” won acclaim among health practitioners after its publication in 1972, with later referral to it establishing the concept. In general, Evidence-based medicine (EBM) consists of five steps: (1) formulation of answerable clinical questions; (2) literature search for the best evidence; (3) critical appraisal of the relevant material; (4) clinical application of the evidence; and, (5) audit of the above.19 Which is the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients.20
As acupuncture is an invasive treatment, safety in clinical application should be closely monitored. We believe that investigations will be quantitatively and qualitatively improved, and that clinical trials will be conducted in accordance with the principles of multi-centre and randomized controlled trials in future. This will allow consensus to be established with respect to the safety and efficacy of acupuncture, allowing this important traditional complementary therapy to keep pace with conventional medical practice and its emergence as a mainstream treatment.
Another key aspect of evidence-based medicine is the collection and dissemination of information to help guide decisions by clinicians, patients and other decision makers.
Overall, acupuncture seems to be relatively safe in the hands of qualified providers, also beneficial, lower side effect(0.14%) by Yamashita,et al.(1999) 21. Although it still present insufficient methodology quality, and the small size of the studies revered. We conclude that migraine headache patients who want to try acupuncture should not be discouraged. In future, may be minimized by improved medical education and technical training of acupuncturists.
References
- International Headache Society Classification Subcommittee Cephalalgia. 2. Vol. 24. 2004. The International Classification of Headache Disorders; pp. 9–160.
- Monzon MJ, Lainez MJ. Quality of life in migraine and chronic daily headache patients. Cephalalgia. 1998; 18:638–643. doi: 10.1046/j.1468-2982.1998.1809638.x
- Fernandez-Concepcion O, Canuet-Delis L. [Disability and quality of life in patients with migraine: determining factors] Rev Neurol. 2003; 36:1105–1112.
- Martinez Eizaguirre JM, Calero MS, Garcia Fernandez ML, Tranche IS, Castillo OJ, Perez II. [Attitudes of Spanish primary care doctors to migraine] Aten Primaria. 2006; 38:33–38. doi: 10.1157/13090029.
- Badia X, Magaz S, Gutierrez L, Galvan J. The burden of migraine in Spain: beyond direct costs. Pharmacoeconomics. 2004; 22:591–603. doi: 10.2165/00019053-200422090-00004.
- Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA. 1992; 267:64–69. doi: 10.1001/jama.267.1.64.
- Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007; 68:343–349. doi: 10.1212/01.wnl.0000252808.97649.21.
- Lipton RB, Bigal ME. The epidemiology of migraine: American Journal of Medicine Supplement.Vol 118, (Suppl 1): 3-10, 2005
- Lipton RB, Stewart WF. Migraine in the United States: epidemiology and health care use. Neurology 43 (Suppl 3): 6-10, 1993
- Migraine Pathophysiology. Headache. 44(7):735-739, 2004.
- Vickers AJ, Rees RW, Zollman CE, McCarney R, Smith CM, Ellis N, Fisher P, Van Haselen R. Acupuncture for chronic headache in primary care: large, pragmatic, randomised trial. BMJ. 328(7442):744, 2004.
- Allais G, De Lorenzo C, Quirico PE, Lupi G, Airola G, Mana O, Benedetto CNon-pharmacological approaches to chronic headaches: transcutaneous electrical nerve stimulation, lasertherapy and acupuncture in transformed migraine treatment. Neurol Sci. 2003 May; 24 Suppl 2:S138-42.
- Lined K, Streng A, Jürgens S, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S, Pfaffenrath V, Hammes MG, Weidenhammer W, Willich SN, Melchart D. Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Munich, Germany. 2005 May 4; 293(17):2118-25.
- Diener, HC et al. Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial. Lancet Neurol. 5(4):310-6, 2006.
- Von Der Laage D. [Acupuncture for headache]. Schmerz 1997; 11(1):4-8.
- Remy R. Coeytaux, Wunian Chen, Catherine E. Lindemuth, Yanmin Tan and, Aimee C. Reilly. The Journal of Alternative and Complementary Medicine. 12(9): 863-872, 2006.
- Melchart, D et al. Acupuncture for recurrent headaches: a systematic review of randomized controlled trials. Cephalalgia 1999; (19):779-86.
- Sutherland SE. Evidence-based dentistry: Part IV. Research design and levels of evidence. J Can Dent Assoc,2001,67: 375-378.
- Yamashiro S. Practice and application of evidence-based medicine. Rinsho Byori,2000,48: 1149-1155.
- Sackett DL. Clinical epidemiology. what, who, and whither. J Clin Epidemiol, 2002, 55: 1161-1166.
- Yamashita H, Tsukayama H, Tanno Y, et al. Adverse events in acupuncture and moxibustion treatment: a six-year survey at a national clinic in Japan. J Altern Complement Med,1999,5: 229-236